Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy

Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes. A series of morphologic...

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Main Authors:	Lili Zhang, Zhige Wen, Lin Han, Yujiao Zheng, Yu Wei, Xinmiao Wang, Qing Wang, Xinyi Fang, Linhua Zhao, Xiaolin Tong
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2020/7504798

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spelling	doaj-50c1770022d849ff993470575f9c94f92020-11-25T03:33:34ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/75047987504798Research Progress on the Pathological Mechanisms of Podocytes in Diabetic NephropathyLili Zhang0Zhige Wen1Lin Han2Yujiao Zheng3Yu Wei4Xinmiao Wang5Qing Wang6Xinyi Fang7Linhua Zhao8Xiaolin Tong9Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGraduate College, Beijing University of Traditional Chinese Medicine, Beijing 100029, ChinaGraduate College, Beijing University of Traditional Chinese Medicine, Beijing 100029, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGraduate College, Beijing University of Traditional Chinese Medicine, Beijing 100029, ChinaGraduate College, Beijing University of Traditional Chinese Medicine, Beijing 100029, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDiabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes. A series of morphological changes after podocyte injury in DN mainly include podocyte hypertrophy, podocyte epithelial-mesenchymal transdifferentiation, podocyte detachment, and podocyte apoptosis; functional changes mainly involve podocyte autophagy. More and more studies have shown that multiple signaling pathways play important roles in the progression of podocyte injury in DN. Here, we review research progress on the pathological mechanism of morphological and functional changes in podocytes associated with DN, to provide a new target for delaying the occurrence and development of this disorder.http://dx.doi.org/10.1155/2020/7504798
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lili Zhang Zhige Wen Lin Han Yujiao Zheng Yu Wei Xinmiao Wang Qing Wang Xinyi Fang Linhua Zhao Xiaolin Tong
spellingShingle	Lili Zhang Zhige Wen Lin Han Yujiao Zheng Yu Wei Xinmiao Wang Qing Wang Xinyi Fang Linhua Zhao Xiaolin Tong Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy Journal of Diabetes Research
author_facet	Lili Zhang Zhige Wen Lin Han Yujiao Zheng Yu Wei Xinmiao Wang Qing Wang Xinyi Fang Linhua Zhao Xiaolin Tong
author_sort	Lili Zhang
title	Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
title_short	Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
title_full	Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
title_fullStr	Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
title_full_unstemmed	Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
title_sort	research progress on the pathological mechanisms of podocytes in diabetic nephropathy
publisher	Hindawi Limited
series	Journal of Diabetes Research
issn	2314-6745 2314-6753
publishDate	2020-01-01
description	Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes. A series of morphological changes after podocyte injury in DN mainly include podocyte hypertrophy, podocyte epithelial-mesenchymal transdifferentiation, podocyte detachment, and podocyte apoptosis; functional changes mainly involve podocyte autophagy. More and more studies have shown that multiple signaling pathways play important roles in the progression of podocyte injury in DN. Here, we review research progress on the pathological mechanism of morphological and functional changes in podocytes associated with DN, to provide a new target for delaying the occurrence and development of this disorder.
url	http://dx.doi.org/10.1155/2020/7504798
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Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy

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