Screening for new peptide substrates for the development of albumin binding anticancer pro-drugs that are cleaved by prostate-specific antigen (PSA) to improve the anti tumor efficacy

Screening for new peptide substrates for the development of albumin binding anticancer pro-drugs that are cleaved by prostate-specific antigen (PSA) to improve the anti tumor efficacy

Several attempts have been made over the past decade to explore the concept of prodrug strategies that exploit PSA as a molecular target for the release of anticancer drugs in prostate tumors using various prostate specific antigen (PSA)-cleavable peptide linkers, but the desired antitumor and antim...

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Bibliographic Details
Main Authors: Bakheet E.M. Elsadek, Mohammed H. Hassan
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Peptide substrate
Prodrug
Spot assay
Prostate-specific antigen (PSA)
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000601

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