Brain-Targeted Delivery of Pre-miR-29b Using Lactoferrin-Stearic Acid-Modified-Chitosan/Polyethyleneimine Polyplexes

Brain-Targeted Delivery of Pre-miR-29b Using Lactoferrin-Stearic Acid-Modified-Chitosan/Polyethyleneimine Polyplexes

The efficacy of brain therapeutics is largely hampered by the presence of the blood–brain barrier (BBB), mainly due to the failure of most (bio) pharmaceuticals to cross it. Accordingly, this study aims to develop nanocarriers for targeted delivery of recombinant precursor microRNA (pre-miR-29b), fo...

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Bibliographic Details
Main Authors: Patrícia Pereira, Maria Barreira, Carla Cruz, Joana Tomás, Ângelo Luís, Augusto Q. Pedro, João A. Queiroz, Fani Sousa
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceuticals
Subjects:
blood–brain barrier
chitosan
drug delivery system
lactoferrin
polyethyleneimine
recombinant miRNA
Online Access:https://www.mdpi.com/1424-8247/13/10/314

Internet

https://www.mdpi.com/1424-8247/13/10/314

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