Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges

Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges

Actinomycetes are the main sources of antibiotics. The onset and level of production of each antibiotic is subject to complex control by multi-level regulators. These regulators exert their functions at hierarchical levels. At the lower level, cluster-situated regulators (CSRs) directly control the...

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Main Authors: Junhong Wei, Lang He, Guoqing Niu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-12-01
Series:Synthetic and Systems Biotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X18300474
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spelling doaj-5099fa54d0504c13ba8896f1af2573bf2021-04-02T09:54:40ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2018-12-0134229235Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challengesJunhong Wei0Lang He1Guoqing Niu2State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing, 400715, China; Academy of Agricultural Sciences, Southwest University, Chongqing, 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing, 400715, China; Academy of Agricultural Sciences, Southwest University, Chongqing, 400715, China; Corresponding author. No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China.Actinomycetes are the main sources of antibiotics. The onset and level of production of each antibiotic is subject to complex control by multi-level regulators. These regulators exert their functions at hierarchical levels. At the lower level, cluster-situated regulators (CSRs) directly control the transcription of neighboring genes within the gene cluster. Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs. Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery. Keywords: Antibiotic biosynthesis, Regulation, Actinomycetes, Genetic manipulation, Strain improvement, Antibiotic discoveryhttp://www.sciencedirect.com/science/article/pii/S2405805X18300474
collection DOAJ
language English
format Article
sources DOAJ
author Junhong Wei
Lang He
Guoqing Niu
spellingShingle Junhong Wei
Lang He
Guoqing Niu
Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
Synthetic and Systems Biotechnology
author_facet Junhong Wei
Lang He
Guoqing Niu
author_sort Junhong Wei
title Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
title_short Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
title_full Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
title_fullStr Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
title_full_unstemmed Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
title_sort regulation of antibiotic biosynthesis in actinomycetes: perspectives and challenges
publisher KeAi Communications Co., Ltd.
series Synthetic and Systems Biotechnology
issn 2405-805X
publishDate 2018-12-01
description Actinomycetes are the main sources of antibiotics. The onset and level of production of each antibiotic is subject to complex control by multi-level regulators. These regulators exert their functions at hierarchical levels. At the lower level, cluster-situated regulators (CSRs) directly control the transcription of neighboring genes within the gene cluster. Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs. Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery. Keywords: Antibiotic biosynthesis, Regulation, Actinomycetes, Genetic manipulation, Strain improvement, Antibiotic discovery
url http://www.sciencedirect.com/science/article/pii/S2405805X18300474
work_keys_str_mv AT junhongwei regulationofantibioticbiosynthesisinactinomycetesperspectivesandchallenges
AT langhe regulationofantibioticbiosynthesisinactinomycetesperspectivesandchallenges
AT guoqingniu regulationofantibioticbiosynthesisinactinomycetesperspectivesandchallenges
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