Characterization of the Ohmyungsamycin Biosynthetic Pathway and Generation of Derivatives with Improved Antituberculosis Activity

Characterization of the Ohmyungsamycin Biosynthetic Pathway and Generation of Derivatives with Improved Antituberculosis Activity

The cyclic depsipeptides ohmyungsamycin (OMS) A (<b>1</b>) and B (<b>2</b>), isolated from the marine-derived <i>Streptomyces</i> sp. SNJ042, contain two non-proteinogenic amino acid residues, <i>&#946;</i>-hydroxy-<span style="font-variant...

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Bibliographic Details
Main Authors: Eunji Kim, Yern-Hyerk Shin, Tae Ho Kim, Woong Sub Byun, Jinsheng Cui, Young Eun Du, Hyung-Ju Lim, Myoung Chong Song, An Sung Kwon, Sang Hyeon Kang, Jongheon Shin, Sang Kook Lee, Jichan Jang, Dong-Chan Oh, Yeo Joon Yoon
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
ohmyungsamycin
marine natural product
nonribosomal peptide synthetase
biosynthetic gene cluster
antituberculosis activity
Online Access:https://www.mdpi.com/2218-273X/9/11/672

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