Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing

Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing

The high mutation rate of the influenza A virus hemagglutinin segment poses great challenges to its long-term effective testing and subtyping. Our conserved sequence searching method achieves high-specificity conserved sequences on H1–H9 subtypes. In addition, PCR experiments show that primers based...

Full description

Bibliographic Details
Main Authors: Qianyu Lin, Xiang Ji, Feng Wu, Lan Ma
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Diagnostics
Subjects:
influenza 1
multiple sequence alignment 2
conserved sequence 3
rapid detection 4
Online Access:https://www.mdpi.com/2075-4418/11/8/1328
id doaj-5097afdeac794010a923734de33aac65
record_format Article
spelling doaj-5097afdeac794010a923734de33aac652021-08-26T13:39:55ZengMDPI AGDiagnostics2075-44182021-07-01111328132810.3390/diagnostics11081328Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid TypingQianyu Lin0Xiang Ji1Feng Wu2Lan Ma3Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, ChinaTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaTsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, ChinaThe high mutation rate of the influenza A virus hemagglutinin segment poses great challenges to its long-term effective testing and subtyping. Our conserved sequence searching method achieves high-specificity conserved sequences on H1–H9 subtypes. In addition, PCR experiments show that primers based on conserved sequences can be used in influenza A virus HA subtyping. Conserved sequence-based primers are expected to be long-term, effective subtyping tools for influenza A virus HA.https://www.mdpi.com/2075-4418/11/8/1328influenza 1multiple sequence alignment 2conserved sequence 3rapid detection 4
collection DOAJ
language English
format Article
sources DOAJ
author Qianyu Lin
Xiang Ji
Feng Wu
Lan Ma
spellingShingle Qianyu Lin
Xiang Ji
Feng Wu
Lan Ma
Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
Diagnostics
influenza 1
multiple sequence alignment 2
conserved sequence 3
rapid detection 4
author_facet Qianyu Lin
Xiang Ji
Feng Wu
Lan Ma
author_sort Qianyu Lin
title Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
title_short Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
title_full Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
title_fullStr Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
title_full_unstemmed Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing
title_sort conserved sequence analysis of influenza a virus ha segment and its application in rapid typing
publisher MDPI AG
series Diagnostics
issn 2075-4418
publishDate 2021-07-01
description The high mutation rate of the influenza A virus hemagglutinin segment poses great challenges to its long-term effective testing and subtyping. Our conserved sequence searching method achieves high-specificity conserved sequences on H1–H9 subtypes. In addition, PCR experiments show that primers based on conserved sequences can be used in influenza A virus HA subtyping. Conserved sequence-based primers are expected to be long-term, effective subtyping tools for influenza A virus HA.
topic influenza 1
multiple sequence alignment 2
conserved sequence 3
rapid detection 4
url https://www.mdpi.com/2075-4418/11/8/1328
work_keys_str_mv AT qianyulin conservedsequenceanalysisofinfluenzaavirushasegmentanditsapplicationinrapidtyping
AT xiangji conservedsequenceanalysisofinfluenzaavirushasegmentanditsapplicationinrapidtyping
AT fengwu conservedsequenceanalysisofinfluenzaavirushasegmentanditsapplicationinrapidtyping
AT lanma conservedsequenceanalysisofinfluenzaavirushasegmentanditsapplicationinrapidtyping
_version_ 1721194012139847680

Similar Items