Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation

Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation

It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific...

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Bibliographic Details
Main Authors: Masato Mashimo, Masayo Komori, Yuriko Y. Matsui, Mami X. Murase, Takeshi Fujii, Shiori Takeshima, Hiromi Okuyama, Shiro Ono, Yasuhiro Moriwaki, Hidemi Misawa, Koichiro Kawashima
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
α7 nAChR
DO11. 10 mouse
GTS-21
regulatory T cells
Th1
Th2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01102/full

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