Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

ABSTRACT The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy levels, growth factors, and hormones, such as insulin, to control anabolic and catabolic processes. We have recently shown that suppression of th...

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Bibliographic Details
Main Authors: Pawanrat Tangseefa, Sally K. Martin, Agnieszka Arthur, Vasilios Panagopoulos, Amanda J. Page, Gary A. Wittert, Christopher G. Proud, Stephen Fitter, Andrew C.W. Zannettino
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:JBMR Plus
Subjects:
BONE MARROW ADIPOSE TISSUE
DIET‐INDUCED INSULIN RESISTANCE
DIET‐INDUCED OBESITY
mTORC1
PREOSTEOBLAST
Online Access:https://doi.org/10.1002/jbm4.10486

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