Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin

Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin

Alcohol abuse and binge drinking are common during adolescence, a developmental period characterized by heightened neuroplasticity. Animal studies reveal that adolescent ethanol exposure decreases hippocampal neurogenesis that persists into adulthood, but the mechanism remains to be fully elucidated...

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Bibliographic Details
Main Authors: Ryan P. Vetreno, Colleen J. Lawrimore, Pamela J. Rowsey, Fulton T. Crews
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neuroscience
Subjects:
cytokines
alcohol
brain development
neuroprogenitors
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00200/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00200/full

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