RNA Virus Reverse Genetics and Vaccine Design

RNA Virus Reverse Genetics and Vaccine Design

RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we...

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Bibliographic Details
Main Authors: Christopher C. Stobart, Martin L. Moore
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Viruses
Subjects:
RNA virus
reverse genetics
vaccines
Online Access:http://www.mdpi.com/1999-4915/6/7/2531
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spelling doaj-507983ba54924fbd9594dc69ea6203d92020-11-24T22:39:30ZengMDPI AGViruses1999-49152014-06-01672531255010.3390/v6072531v6072531RNA Virus Reverse Genetics and Vaccine DesignChristopher C. Stobart0Martin L. Moore1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USARNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines.http://www.mdpi.com/1999-4915/6/7/2531RNA virusreverse geneticsvaccines
collection DOAJ
language English
format Article
sources DOAJ
author Christopher C. Stobart
Martin L. Moore
spellingShingle Christopher C. Stobart
Martin L. Moore
RNA Virus Reverse Genetics and Vaccine Design
Viruses
RNA virus
reverse genetics
vaccines
author_facet Christopher C. Stobart
Martin L. Moore
author_sort Christopher C. Stobart
title RNA Virus Reverse Genetics and Vaccine Design
title_short RNA Virus Reverse Genetics and Vaccine Design
title_full RNA Virus Reverse Genetics and Vaccine Design
title_fullStr RNA Virus Reverse Genetics and Vaccine Design
title_full_unstemmed RNA Virus Reverse Genetics and Vaccine Design
title_sort rna virus reverse genetics and vaccine design
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2014-06-01
description RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines.
topic RNA virus
reverse genetics
vaccines
url http://www.mdpi.com/1999-4915/6/7/2531
work_keys_str_mv AT christophercstobart rnavirusreversegeneticsandvaccinedesign
AT martinlmoore rnavirusreversegeneticsandvaccinedesign
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