An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

Abstract Background Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we identify specific cell types that generate IL-1β and h...

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Bibliographic Details
Main Authors: Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera, Sylvain Chemtob
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Retinal degeneration
Photoreceptors
cell death
Inflammation
Inflammasome
Interleukin-1
Online Access:https://doi.org/10.1186/s12974-020-02032-8

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