Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis

Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis

The prognosis of oral squamous cell carcinoma (OSCC) largely depends on the control of lymph node metastases. We evaluate the therapeutic efficacy of G47Δ, a third-generation oncolytic herpes simplex virus type 1 (HSV-1), in mouse tongue cancer models. Intratumoral injection with G47Δ prolonged the...

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Bibliographic Details
Main Authors: Toshihiro Uchihashi, Hirokazu Nakahara, Hiroshi Fukuhara, Miwako Iwai, Hirotaka Ito, Akinari Sugauchi, Minoru Tanaka, Mikihiko Kogo, Tomoki Todo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
G47Δ
oncolytic virus therapy
lymph node metastasis
tongue cancer
antitumor immunity
oral squamous cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000887

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http://www.sciencedirect.com/science/article/pii/S2372770521000887

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