Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

• Main Authors: Thaís Heinke, Kleber Simões do Espiríto Santo, Adhemar Longatto Filho, João Norberto Stavale
• Format: Article
• Language: English
• Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2013-01-01
• Series: Acta Cirurgica Brasileira
• Subjects: Glioma; Neovascularization, Pathologic; Immunohistochemistry
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008
• ISSN: 0102-8650; 1678-2674

PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.