New Furanocembranoids from Briareum violaceum

Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum<...

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Main Authors:	Pin-Chang Huang, Wen-Sou Lin, Bo-Rong Peng, Yu-Chia Chang, Lee-Shing Fang, Guo-Qiang Li, Tsong-Long Hwang, Zhi-Hong Wen, Ping-Jyun Sung
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Marine Drugs
Subjects:	<i>Briareum violaceum</i> briaviodiol briaviotriol anti-inflammatory iNOS
Online Access:	https://www.mdpi.com/1660-3397/17/4/214

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spelling	doaj-50544bcd506d4ddbae988f8a8836b0cb2020-11-25T01:56:26ZengMDPI AGMarine Drugs1660-33972019-04-0117421410.3390/md17040214md17040214New Furanocembranoids from <i>Briareum violaceum</i>Pin-Chang Huang0Wen-Sou Lin1Bo-Rong Peng2Yu-Chia Chang3Lee-Shing Fang4Guo-Qiang Li5Tsong-Long Hwang6Zhi-Hong Wen7Ping-Jyun Sung8Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, TaiwanDepartment of Neurology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, TaiwanDepartment of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, TaiwanResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, TaiwanCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, TaiwanKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266033, ChinaResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, TaiwanThree new furanocembranoids—briaviodiol F (<b>1</b>) and briaviotriols A (<b>2</b>) and B (<b>3</b>)—along with a known analogue, briaviodiol A (<b>4</b>), were obtained from a cultured-type octocoral <i>Briareum violaceum</i>. The structures of cembranoids <b>1</b>–<b>3</b> were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds <b>2</b> and <b>4</b> exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.https://www.mdpi.com/1660-3397/17/4/214<i>Briareum violaceum</i>briaviodiolbriaviotriolanti-inflammatoryiNOS
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pin-Chang Huang Wen-Sou Lin Bo-Rong Peng Yu-Chia Chang Lee-Shing Fang Guo-Qiang Li Tsong-Long Hwang Zhi-Hong Wen Ping-Jyun Sung
spellingShingle	Pin-Chang Huang Wen-Sou Lin Bo-Rong Peng Yu-Chia Chang Lee-Shing Fang Guo-Qiang Li Tsong-Long Hwang Zhi-Hong Wen Ping-Jyun Sung New Furanocembranoids from <i>Briareum violaceum</i> Marine Drugs <i>Briareum violaceum</i> briaviodiol briaviotriol anti-inflammatory iNOS
author_facet	Pin-Chang Huang Wen-Sou Lin Bo-Rong Peng Yu-Chia Chang Lee-Shing Fang Guo-Qiang Li Tsong-Long Hwang Zhi-Hong Wen Ping-Jyun Sung
author_sort	Pin-Chang Huang
title	New Furanocembranoids from <i>Briareum violaceum</i>
title_short	New Furanocembranoids from <i>Briareum violaceum</i>
title_full	New Furanocembranoids from <i>Briareum violaceum</i>
title_fullStr	New Furanocembranoids from <i>Briareum violaceum</i>
title_full_unstemmed	New Furanocembranoids from <i>Briareum violaceum</i>
title_sort	new furanocembranoids from <i>briareum violaceum</i>
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-04-01
description	Three new furanocembranoids—briaviodiol F (<b>1</b>) and briaviotriols A (<b>2</b>) and B (<b>3</b>)—along with a known analogue, briaviodiol A (<b>4</b>), were obtained from a cultured-type octocoral <i>Briareum violaceum</i>. The structures of cembranoids <b>1</b>–<b>3</b> were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds <b>2</b> and <b>4</b> exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.
topic	<i>Briareum violaceum</i> briaviodiol briaviotriol anti-inflammatory iNOS
url	https://www.mdpi.com/1660-3397/17/4/214
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New Furanocembranoids from <i>Briareum violaceum</i>

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