Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model

Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model

Neuroprotection has proven clinically unsuccessful in subarachnoid hemorrhage. We believe that this is because the major component in the early damage pathway, the vascular wall, has not been given the necessary focus. U0126 is a potent inhibitor of vascular phenotypical changes, exemplified by func...

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Bibliographic Details
Main Authors: S. T. Christensen, A. S. Grell, S. E. Johansson, C. M. Andersson, L. Edvinsson, K. A. Haanes
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
basilar artery
cremophor el
endothelin-1
mek1/2
optimal dose
u0126
Online Access:http://dx.doi.org/10.1080/10717544.2019.1636421

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