Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Abstract Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency. We hypothesis that emodin suppresses lung cancer cells t...

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Bibliographic Details
Main Authors: Mingzhu Li, Shengbo Jin, Yang Cao, Jian Xu, Shendong Zhu, Zheng Li
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
NSCLC
HAS
CD44
RHAMM
Cell cycle
Online Access:https://doi.org/10.1186/s12935-020-01711-z

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