Osteopontin in chronic obstructive pulmonary disease: Smokers and ex-smokers

• Main Authors: Ahmed A Ali, Nourane Y. Azab, Ibrahim I. El-Mahalawy, Safaa I. Tayel, Ehab M. Khalifa
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Egyptian Journal of Chest Disease and Tuberculosis
• Subjects: Osteopontin; Smokers; Ex-smokers; COPD
• Online Access: http://www.sciencedirect.com/science/article/pii/S0422763814200550

Background: COPD is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between osteopontin, smoking and COPD needs to be clarified. Objectives: To study the osteopontin serum levels in smoker COPD patients and ex-smoker COPD patients. Methods: Serum levels of osteopontin were measured in 38 male COPD patients divided into smoker and ex-smoker groups using human osteopontin ELISA kits. Results: There was a significant difference between smokers and ex-smokers regarding their serum osteopontin levels. There was no significant difference in serum osteopontin level between COPD patients regarding severity in both groups. There was a significant difference in serum osteopontin level between the smokers group regarding their pack year index of smoking. There was no significant difference in serum osteopontin level between ex-smokers group regarding the duration of cessation. Conclusion: Serum level of osteopontin is increased in COPD patients and decreases with cessation of smoking. It has no relation to disease severity.