Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells.

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells.

Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. While diabetes leads to a decr...

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Bibliographic Details
Main Authors: Kayla Thompson, Jonathan Chen, Qianyi Luo, Yucheng Xiao, Theodore R Cummins, Ashay D Bhatwadekar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5825079?pdf=render

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