Two Cases of Fatal Encephalopathy Related to Ifosfamide: An Adverse Role of Aprepitant

Two Cases of Fatal Encephalopathy Related to Ifosfamide: An Adverse Role of Aprepitant

Ifosfamide is used in the treatment of sarcomas and other tumors. It sometimes provokes encephalopathy, which is a serious complication even if it is usually reversible within 48-72 h after drug cessation. Ifosfamide is required to be activated by hepatic cytochrome P450 (CYP), especially the 3A4 su...

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Bibliographic Details
Main Authors: Alice Séjourné, Sabine Noal, Mathieu Boone, Céline Bihan, Marion Sassier, Michel Andrejak, Bruno Chauffert
Format: Article
Language:English
Published: Karger Publishers 2014-09-01
Series:Case Reports in Oncology
Subjects:
Aprepitant
Ifosfamide
Encephalopathy
Drug interaction
Online Access:http://www.karger.com/Article/FullText/368184

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