BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury.

BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury.

Peripheral nerve injury-induced mechanical allodynia is often accompanied by abnormalities in the higher cortical regions, yet the mechanisms underlying such maladaptive cortical plasticity remain unclear. Here, we show that in male mice, structural and functional changes in the primary somatosensor...

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Bibliographic Details
Main Authors: Lianyan Huang, Jianhua Jin, Kai Chen, Sikun You, Hongyang Zhang, Alexandra Sideris, Monica Norcini, Esperanza Recio-Pinto, Jing Wang, Wen-Biao Gan, Guang Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001337

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https://doi.org/10.1371/journal.pbio.3001337

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