Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate

Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate

To solve the inhibition mechanism of thymidylate synthase (TS) by N4-hydroxy-dCMP (N4-OH-dCMP), crystallographic studies were undertaken. Structures of three mouse TS (mTS) complexes with the inhibitor were solved, based on crystals formed by the enzyme protein in the presence of either only N4-OH-d...

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Bibliographic Details
Main Authors: Dowierciał Anna, Jarmuła Adam, Wilk Piotr, Rypniewski Wojciech, Kierdaszuk Borys, Rode Wojciech
Format: Article
Language:English
Published: De Gruyter 2013-06-01
Series:Pteridines
Subjects:
3d structure
inhibition
thymidylate synthase
enzymes: thymidylate synthase (ec 2.1.1.45)
pdb reference: thymidylate synthase; 4ein (the crystal a-based structure); 4ez8 (the crystal c-based structure)
Online Access:https://doi.org/10.1515/pterid-2013-0010

Internet

https://doi.org/10.1515/pterid-2013-0010

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