BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway

BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway

Sepsis is a life-threatening state of organ dysfunction caused by infection and which can induce severe neurological disorders that lead to neuroinflammation and cognitive impairment. Inflammation has been reported to cause neuronal apoptosis in sepsis, which can finally lead to cognitive impairment...

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Bibliographic Details
Main Authors: Shangwen Pan, Yan Wu, Lei Pei, Shengnan Li, Limin Song, Haifa Xia, Yaxin Wang, Yuan Yu, Xiaobo Yang, Huaqing Shu, Jiancheng Zhang, Shiying Yuan, You Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
sepsis
neuroinflammation
cognitive impairment
BML-111
SIRT1
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00267/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00267/full

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