Single-molecule theory of enzymatic inhibition

Single-molecule theory of enzymatic inhibition

Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.

Bibliographic Details
Main Authors: Tal Robin, Shlomi Reuveni, Michael Urbakh
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02995-6
id doaj-4ff682a5b6ec47f9b1d180b0cef1fdf2
record_format Article
spelling doaj-4ff682a5b6ec47f9b1d180b0cef1fdf22021-05-11T09:46:34ZengNature Publishing GroupNature Communications2041-17232018-02-01911910.1038/s41467-018-02995-6Single-molecule theory of enzymatic inhibitionTal Robin0Shlomi Reuveni1Michael Urbakh2School of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySchool of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySchool of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySingle molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.https://doi.org/10.1038/s41467-018-02995-6
collection DOAJ
language English
format Article
sources DOAJ
author Tal Robin
Shlomi Reuveni
Michael Urbakh
spellingShingle Tal Robin
Shlomi Reuveni
Michael Urbakh
Single-molecule theory of enzymatic inhibition
Nature Communications
author_facet Tal Robin
Shlomi Reuveni
Michael Urbakh
author_sort Tal Robin
title Single-molecule theory of enzymatic inhibition
title_short Single-molecule theory of enzymatic inhibition
title_full Single-molecule theory of enzymatic inhibition
title_fullStr Single-molecule theory of enzymatic inhibition
title_full_unstemmed Single-molecule theory of enzymatic inhibition
title_sort single-molecule theory of enzymatic inhibition
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.
url https://doi.org/10.1038/s41467-018-02995-6
work_keys_str_mv AT talrobin singlemoleculetheoryofenzymaticinhibition
AT shlomireuveni singlemoleculetheoryofenzymaticinhibition
AT michaelurbakh singlemoleculetheoryofenzymaticinhibition
_version_ 1721449275204829184

Similar Items