Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe2+ Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide

Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe2+ Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide

Pyrazinamide (PZA) is the first-line drug commonly used in treating Mycobacterium tuberculosis (Mtb) infections and reduces treatment time by 33%. This prodrug is activated and converted to an active form, Pyrazinoic acid (POA), by Pyrazinamidase (PZase) enzyme. Mtb resistance to PZA is the outcome...

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Bibliographic Details
Main Authors: Asma Sindhoo Nangraj, Abbas Khan, Shaheena Umbreen, Sana Sahar, Maryam Arshad, Saba Younas, Sajjad Ahmad, Shahid Ali, Syed Shujait Ali, Liaqat Ali, Dong-Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
PZA
simulation
mutations
PCA
free energy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.633365/full

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