The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures

Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmen...

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Main Authors: Tao Zhu, Anthony P Brown, Hong Ji
Format: Article
Language:English
Published: SAGE Publishing 2020-03-01
Series:Epigenetics Insights
Online Access:https://doi.org/10.1177/2516865720910155
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spelling doaj-4fea557b824b4009a035dcd5c1ce1e1e2020-11-25T03:37:11ZengSAGE PublishingEpigenetics Insights2516-86572020-03-011310.1177/2516865720910155The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental ExposuresTao Zhu0Anthony P Brown1Hong Ji2California National Primate Research Center, University of California, Davis, Davis, CA, USACalifornia National Primate Research Center, University of California, Davis, Davis, CA, USADepartment of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, USAMounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases.https://doi.org/10.1177/2516865720910155
collection DOAJ
language English
format Article
sources DOAJ
author Tao Zhu
Anthony P Brown
Hong Ji
spellingShingle Tao Zhu
Anthony P Brown
Hong Ji
The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
Epigenetics Insights
author_facet Tao Zhu
Anthony P Brown
Hong Ji
author_sort Tao Zhu
title The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
title_short The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
title_full The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
title_fullStr The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
title_full_unstemmed The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
title_sort emerging role of ten-eleven translocation 1 in epigenetic responses to environmental exposures
publisher SAGE Publishing
series Epigenetics Insights
issn 2516-8657
publishDate 2020-03-01
description Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases.
url https://doi.org/10.1177/2516865720910155
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