Pedunculopontine arousal system physiology—Implications for schizophrenia

Pedunculopontine arousal system physiology—Implications for schizophrenia

Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is al...

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Main Authors: Edgar Garcia-Rill, Stasia D’Onofrio, Susan Mahaffey, Veronica Bisagno, Francisco J. Urbano
Format: Article
Language:English
Published: Brazilian Association of Sleep and Latin American Federation of Sleep Societies 2015-04-01
Series:Sleep Science
Subjects:
Calcium channels
Gamma band activity
Neuronal calcium sensor protein
P50 potential
Online Access:http://www.sciencedirect.com/science/article/pii/S1984006315000322
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spelling doaj-4fe2d7a745794527870937dfd37ca3032020-11-24T22:58:21ZengBrazilian Association of Sleep and Latin American Federation of Sleep Societies Sleep Science1984-00632015-04-0182829110.1016/j.slsci.2015.04.003Pedunculopontine arousal system physiology—Implications for schizophreniaEdgar Garcia-Rill0Stasia D’Onofrio1Susan Mahaffey2Veronica Bisagno3Francisco J. Urbano4Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesCenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesCenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Buenos Aires, ArgentinaIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Buenos Aires, ArgentinaSchizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia.http://www.sciencedirect.com/science/article/pii/S1984006315000322Calcium channelsGamma band activityNeuronal calcium sensor proteinP50 potential
collection DOAJ
language English
format Article
sources DOAJ
author Edgar Garcia-Rill
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
spellingShingle Edgar Garcia-Rill
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
Pedunculopontine arousal system physiology—Implications for schizophrenia
Sleep Science
Calcium channels
Gamma band activity
Neuronal calcium sensor protein
P50 potential
author_facet Edgar Garcia-Rill
Stasia D’Onofrio
Susan Mahaffey
Veronica Bisagno
Francisco J. Urbano
author_sort Edgar Garcia-Rill
title Pedunculopontine arousal system physiology—Implications for schizophrenia
title_short Pedunculopontine arousal system physiology—Implications for schizophrenia
title_full Pedunculopontine arousal system physiology—Implications for schizophrenia
title_fullStr Pedunculopontine arousal system physiology—Implications for schizophrenia
title_full_unstemmed Pedunculopontine arousal system physiology—Implications for schizophrenia
title_sort pedunculopontine arousal system physiology—implications for schizophrenia
publisher Brazilian Association of Sleep and Latin American Federation of Sleep Societies
series Sleep Science
issn 1984-0063
publishDate 2015-04-01
description Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia.
topic Calcium channels
Gamma band activity
Neuronal calcium sensor protein
P50 potential
url http://www.sciencedirect.com/science/article/pii/S1984006315000322
work_keys_str_mv AT edgargarciarill pedunculopontinearousalsystemphysiologyimplicationsforschizophrenia
AT stasiadonofrio pedunculopontinearousalsystemphysiologyimplicationsforschizophrenia
AT susanmahaffey pedunculopontinearousalsystemphysiologyimplicationsforschizophrenia
AT veronicabisagno pedunculopontinearousalsystemphysiologyimplicationsforschizophrenia
AT franciscojurbano pedunculopontinearousalsystemphysiologyimplicationsforschizophrenia
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