Saponinas antifúngicas de Swartzia langsdorffii Antifungal saponins from Swartzia langsdorffii

• Main Authors: Sara Regina de Marqui, Renata Brionízio Lemos, Luciana Ávila Santos, Ian Castro-Gamboa, Alberto José Cavalheiro, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva, Liliana Scorzoni, Ana Maria Fusco-Almeida, Maria José Soares Mendes-Giannini, Maria Claudia Marx Young, Luce Maria Brandão Torres
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2008-01-01
• Series: Química Nova
• Subjects: Swartzia langsdorffii; saponins; antifungal activity
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400023

<abstract language="eng">Chromatographic fractionation of the EtOH extract from the leaves of Swartzia langsdorffii afforded the pentacyclic triterpenes oleanolic acid and lupeol, and two saponins: oleanolic acid 3-sophoroside and the new ester 3-O-b-D-(6'-methyl)-glucopyranosyl-28-O-b-D-glucopyranosyl-oleanate. Their structures were elucidated from spectral data, including 2D NMR and HRESIMS experiments. Antifungal activity of all isolated compounds was evaluated, using phytopathogens Cladosporium cladosporioides and C. sphaerospermum, and human pathogens Candida albicans, C. krusei, C. parapsilosis and Cryptococcus neoformans.