Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling

• Main Authors: Shaik Lahoor Basha, PharmD, Sake Suresh, MD, V.V. Ashok Reddy, MD, S P Surya Teja, PhD
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Clinical Epidemiology and Global Health
• Subjects: Cathelicidin; Latitude; Influenza; Pneumonia; Diabetes; Hypertension
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213398420302256

Despite being announced as a global health concern and emergency in January by WHO, designing specific treatment for SARS-CoV-2 is still a summit yet to be conquered. Currently, many drugs are being tested in the clinical scenario and vitamins play a significant role in therapeutic management. Based on the available evidence, we postulate that maintaining normal vitamin D3 levels may reduce severity, mortality risk of COVID-19. This review elucidates the alarming need for randomized clinical trials to determine the role of vitamin D in patient prognosis in COVID-19 infection and on latitude bases epidemiological outcome.