| Summary: | The chalcone of p-bromoacetophenone and p-chlorobenzaldehyde was prepared and converted into aminopyrimidine by treating with guanidine nitrate. The aminopyrimidines so obtained were converted into Schiff bases by treating with different substituted benzaldehydes. The structures of synthesized compounds were confirmed by physical parameters and spectral studies such as UV, IR, and PMR. The synthesized Schiff bases were screened with different bacterial species for the antibacterial activity by cup plate method and serial dilution technique. The confirmation of the biological activity of the final compounds was established by bioautography. The mono and dihydroxy amino pyrimidines (I-g, I-j) of the novel series were found to be potential against bacteria. Keywords: Chalcone, 2-Aminopyrimidine, Schiff bases, Antibacterial activity, Bioautography, Spectral studies
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