Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases

Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases

Structural and functional studies have provided numerous insights over the past years on how members of the nuclear hormone receptor superfamily tightly regulate the expression of drug-metabolizing enzymes and transporters. Besides the role of the farnesoid X receptor (FXR) in the transcriptional co...

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Bibliographic Details
Main Authors: Manon Garcia, Laura Thirouard, Lauriane Sedès, Mélusine Monrose, Hélène Holota, Françoise Caira, David H. Volle, Claude Beaudoin
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
FXR
PXR
CAR
bile acids
xenobiotics
metabolism and transport
cancer
drug resistance
Online Access:https://www.mdpi.com/1422-0067/19/11/3630

Internet

https://www.mdpi.com/1422-0067/19/11/3630

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