Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats

Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene that inactivate expression of the gene product, the fragile X mental retardation 1 protein (FMRP). In this study, we used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

Full description

Bibliographic Details
Main Authors: Yonglu Tian, Chaojuan Yang, Shujiang Shang, Yijun Cai, Xiaofei Deng, Jian Zhang, Feng Shao, Desheng Zhu, Yunbo Liu, Guiquan Chen, Jing Liang, Qiang Sun, Zilong Qiu, Chen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
FXS
hippocampus
long-term plasticity
spatial learning
intellectual disability
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00269/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00269/full

Similar Items