Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Esch...

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Main Authors:	Joseph Kwasi Adu, Cedric Dzidzor Kodjo Amengor, Nurudeen Mohammed Ibrahim, Cynthia Amaning-Danquah, Charles Owusu Ansah, Dorcas Dzifa Gbadago, Joseph Sarpong-Agyapong
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Journal of Tropical Medicine
Online Access:	http://dx.doi.org/10.1155/2020/4850492

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spelling	doaj-4fce2ab6262e4e8d9d660f938acadc012020-11-25T03:26:59ZengHindawi LimitedJournal of Tropical Medicine1687-96861687-96942020-01-01202010.1155/2020/48504924850492Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo DyesJoseph Kwasi Adu0Cedric Dzidzor Kodjo Amengor1Nurudeen Mohammed Ibrahim2Cynthia Amaning-Danquah3Charles Owusu Ansah4Dorcas Dzifa Gbadago5Joseph Sarpong-Agyapong6Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Health and Allied Sciences, Ho, GhanaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaThe antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.http://dx.doi.org/10.1155/2020/4850492
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Joseph Kwasi Adu Cedric Dzidzor Kodjo Amengor Nurudeen Mohammed Ibrahim Cynthia Amaning-Danquah Charles Owusu Ansah Dorcas Dzifa Gbadago Joseph Sarpong-Agyapong
spellingShingle	Joseph Kwasi Adu Cedric Dzidzor Kodjo Amengor Nurudeen Mohammed Ibrahim Cynthia Amaning-Danquah Charles Owusu Ansah Dorcas Dzifa Gbadago Joseph Sarpong-Agyapong Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes Journal of Tropical Medicine
author_facet	Joseph Kwasi Adu Cedric Dzidzor Kodjo Amengor Nurudeen Mohammed Ibrahim Cynthia Amaning-Danquah Charles Owusu Ansah Dorcas Dzifa Gbadago Joseph Sarpong-Agyapong
author_sort	Joseph Kwasi Adu
title	Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_short	Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_full	Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_fullStr	Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_full_unstemmed	Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_sort	synthesis and in vitro antimicrobial and anthelminthic evaluation of naphtholic and phenolic azo dyes
publisher	Hindawi Limited
series	Journal of Tropical Medicine
issn	1687-9686 1687-9694
publishDate	2020-01-01
description	The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.
url	http://dx.doi.org/10.1155/2020/4850492
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Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

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