UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis

<p class="orbitalabstract">In the present article it is described the validation of a simple, precise, accurate, rapid and low-cost UV spectrophotometric method for quantification of paracetamol in tablets. The method was linear in the range between 6.4 - 9.6 μg mL<sup>-1</s...

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Bibliographic Details
Main Authors: Enock José Alves Goes Junior, Jakson Santos Roeder, Kaiky Borges Lima Oliveira, Lucas de Castro Goes, Mateus Pereira Ferreira, Jonatas Gomes da Silva
Format: Article
Language:English
Published: Universidade Federal de Mato Grosso do Sul 2018-12-01
Series:Orbital: The Electronic Journal of Chemistry
Subjects:
Online Access:http://orbital.ufms.br/index.php/Chemistry/article/view/1330
Description
Summary:<p class="orbitalabstract">In the present article it is described the validation of a simple, precise, accurate, rapid and low-cost UV spectrophotometric method for quantification of paracetamol in tablets. The method was linear in the range between 6.4 - 9.6 μg mL<sup>-1</sup>, presenting a good correlation coefficient (r = 0.9984) and adequate limits of quantification (2.64 μg mL<sup>-1</sup>) and detection (0.87 μg mL<sup>-1</sup>). Precision and analysis showed low coefficient of variation (&lt; 4.0 %) and a good average recovery percentual (99.22% - reference and 101.78% - generic) was obtained. The method was applied for paracetamol determination in two tablet formulations and these results are in good accordance with the declared values of manufacturer, at a 95% confidence level. The experimental activity is simple, showing it to be used in experimental activities on teaching laboratories improve student learning.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v10i7.1330">http://dx.doi.org/10.17807/orbital.v10i7.1330</a></p>
ISSN:1984-6428