Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection

• Main Author: O. B. Zhoukova
• Format: Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 2006-09-01
• Series: Bûlleten' Sibirskoj Mediciny
• Subjects: лимфоцит; хроническая вирусная инфекция; апоптоз; fas-рецептор; tnf-рецептор; мембранный потенциал митохондрий; lymphocyte; chronic viral infection; apoptosis; fas-receptor; tnf-receptor; mitochondrial membrane potential
• Online Access: https://bulletin.tomsk.ru/jour/article/view/3084
• ISSN: 1682-0363; 1819-3684

Programmed cell death of lymphocytes in patients with chronic infections induced by tick-borne encephalitis, hepatites B and C was investigated. The injury character in realization of lymphocyte apoptosis is shown to depend on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after their incubation in vitro with dexamethazone, etopozide and in the environment without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction ways are preferably modulated in chronic virus persistence.