Treatment Effects of the Second-Generation Tyrosine Kinase Inhibitor Dasatinib on Autoimmune Arthritis

Treatment Effects of the Second-Generation Tyrosine Kinase Inhibitor Dasatinib on Autoimmune Arthritis

Rheumatoid arthritis (RA) is a multifactorial autoimmune disease that primarily manifests as persistent synovitis and progressive joint destruction. Imatinib exhibited a therapeutic effect in murine collagen-induced arthritis (CIA) via selective inhibition tyrosine kinases. The second-generation tyr...

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Bibliographic Details
Main Authors: Kai Guo, Xin Bu, Chongfei Yang, Xiaorui Cao, Huan Bian, Qingsheng Zhu, Jinyu Zhu, Dawei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
dasatinib
fibroblast-like synoviocyte
collagen-induced arthritis
tyrosine kinase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03133/full

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