Combined Hereditary Spherocytosis and β-thalassemia trait: A Rare Co-existence

• Main Authors: Hanaganahalli Basavaiah Sridevi, Saraswathy Sreeram, Anupama Hegde, Prashantha Balanthimogru, Shrijeet Chakraborti
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2018-01-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: haemoglobinopathies; hepatosplenomegaly; liquid chromatography; osmotic fragility
• Online Access: https://jcdr.net/articles/PDF/11072/31302_230118_31302_CE(RA1)_F(T)_PF1(PG_GG)_PFA(VJ_AP)PFA(MJ_AnG)_PN(AP).pdf

Haemoglobinopathies are the commonest haemolytic disorders, prevalent in India and form a major bulk of patients in most of the haematology outpatient clinics. β-thalassaemia is the commonest inherited haemolytic anaemia and presence of β-Thalassaemia Trait (BTT) goes mostly undetected due to its asymptomatic clinical course. However, BTT should be diagnosed so as to conduct a genetic counselling and to prevent the number of births of affected children in turn reducing the financial burden on the affected family. Detection of combined haemolytic anaemia is on a rise due to better screening modalities in haemoglobinopathies. We hereby present two cases of combined BTT and Hereditary Spherocytosis (HS), and their clinical outcome.