Focal Scn1a knockdown induces cognitive impairment without seizures
Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a fundamental question is whether underlying brain abnormalities may contribute to cognitive impairment through m...
Main Authors: | Alex C. Bender, Heather Natola, Christian Ndong, Gregory L. Holmes, Rod C. Scott, Pierre-Pascal Lenck-Santini |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-06-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996113000120 |
Similar Items
-
Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance
by: Christopher D. Makinson, et al.
Published: (2014-08-01) -
Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
by: Lucia Mora-Jimenez, et al.
Published: (2021-09-01) -
L’effet des crises épileptiques sur les fonctions cognitives et comportementales des modèles murins portant la mutation du gène Scn1a : implication dans le Syndrome de Dravet
by: Salgueiro Pereira, Ana Rita
Published: (2017) -
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
by: Yishan Sun, et al.
Published: (2016-07-01) -
Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
by: Jens Schuster, et al.
Published: (2019-12-01)