Focal Scn1a knockdown induces cognitive impairment without seizures

Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a fundamental question is whether underlying brain abnormalities may contribute to cognitive impairment through m...

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Bibliographic Details
Main Authors: Alex C. Bender, Heather Natola, Christian Ndong, Gregory L. Holmes, Rod C. Scott, Pierre-Pascal Lenck-Santini
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000120