Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study

Melioidosis is a tropical infectious disease with diverse clinical presentations. We aimed to investigate the characteristics and mortality risk factors of patients diagnosed with melioidosis in the past 10 years. This was a retrospective cohort study conducted at a quaternary care centre in South I...

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Main Authors: Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2021/8154810
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spelling doaj-4f860e394bcf4bbdb5edbbb1e3cccbc52021-07-19T01:03:58ZengHindawi LimitedThe Scientific World Journal1537-744X2021-01-01202110.1155/2021/8154810Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort StudyRaviraj Menon0Poornima Baby1Anil Kumar V.2Sandeep Surendran3Manu Pradeep4Aiswarya Rajendran5Gaayathri Suju6Arathy Ashok7Department of General MedicineDepartment of MicrobiologyDepartment of MicrobiologyDepartment of RheumatologyDepartment of Community MedicineUniversity of MassachusettsAmrita School of MedicineDepartment of MicrobiologyMelioidosis is a tropical infectious disease with diverse clinical presentations. We aimed to investigate the characteristics and mortality risk factors of patients diagnosed with melioidosis in the past 10 years. This was a retrospective cohort study conducted at a quaternary care centre in South India. Clinical, demographic, and biochemical data in patients diagnosed with melioidosis with cultures were collected between January 2011 and December 2020 from medical records. Logistic regression analysis was performed to screen mortality risk factors of melioidosis in addition to descriptive statistics and chi-square analysis. Seventy-three melioidosis patients’ records were analysed, and the most common comorbidity was type 2 diabetes mellitus (n = 53, 72.6%). The patients showed diverse presentations: pulmonary involvement, 30 (41.1%); splenomegaly, 29 (39.7%); abscesses and cutaneous involvement, 18 (24.7%); lymph node, 10 (13.7%); arthritis and osteomyelitis, 9 (12.3%); and genitourinary infection, 4 (5.4%). The mortality was noted to be 15 (20.5%). Logistic regression analysis indicated that chronic kidney disease (OR = 14.0), CRP >100 IU/L (OR = 6.964), and S. albumin <3 gm/dl (OR = 8.0) were risk factors associated with mortality and can guide in risk stratification. Hypoalbuminemia is a novel mortality risk factor, detected in this study, and requires further investigation to validate its utility as a prognostic marker and reveal possible therapeutic benefits in clinical correction.http://dx.doi.org/10.1155/2021/8154810
collection DOAJ
language English
format Article
sources DOAJ
author Raviraj Menon
Poornima Baby
Anil Kumar V.
Sandeep Surendran
Manu Pradeep
Aiswarya Rajendran
Gaayathri Suju
Arathy Ashok
spellingShingle Raviraj Menon
Poornima Baby
Anil Kumar V.
Sandeep Surendran
Manu Pradeep
Aiswarya Rajendran
Gaayathri Suju
Arathy Ashok
Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
The Scientific World Journal
author_facet Raviraj Menon
Poornima Baby
Anil Kumar V.
Sandeep Surendran
Manu Pradeep
Aiswarya Rajendran
Gaayathri Suju
Arathy Ashok
author_sort Raviraj Menon
title Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
title_short Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
title_full Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
title_fullStr Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
title_full_unstemmed Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study
title_sort risk factors for mortality in melioidosis: a single-centre, 10-year retrospective cohort study
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2021-01-01
description Melioidosis is a tropical infectious disease with diverse clinical presentations. We aimed to investigate the characteristics and mortality risk factors of patients diagnosed with melioidosis in the past 10 years. This was a retrospective cohort study conducted at a quaternary care centre in South India. Clinical, demographic, and biochemical data in patients diagnosed with melioidosis with cultures were collected between January 2011 and December 2020 from medical records. Logistic regression analysis was performed to screen mortality risk factors of melioidosis in addition to descriptive statistics and chi-square analysis. Seventy-three melioidosis patients’ records were analysed, and the most common comorbidity was type 2 diabetes mellitus (n = 53, 72.6%). The patients showed diverse presentations: pulmonary involvement, 30 (41.1%); splenomegaly, 29 (39.7%); abscesses and cutaneous involvement, 18 (24.7%); lymph node, 10 (13.7%); arthritis and osteomyelitis, 9 (12.3%); and genitourinary infection, 4 (5.4%). The mortality was noted to be 15 (20.5%). Logistic regression analysis indicated that chronic kidney disease (OR = 14.0), CRP >100 IU/L (OR = 6.964), and S. albumin <3 gm/dl (OR = 8.0) were risk factors associated with mortality and can guide in risk stratification. Hypoalbuminemia is a novel mortality risk factor, detected in this study, and requires further investigation to validate its utility as a prognostic marker and reveal possible therapeutic benefits in clinical correction.
url http://dx.doi.org/10.1155/2021/8154810
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