The Paracrine Effect of Skeletal Myoblasts is Cardioprotective against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response

The Paracrine Effect of Skeletal Myoblasts is Cardioprotective against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response

Therapeutic effects of skeletal myoblast transplantation into the myocardium are mediated via paracrine factors. We investigated the ability of myoblast-derived soluble mediators to protect cardiomyocytes from oxidative stress. Fetal rat cardiac cells were treated with conditioned medium from cultur...

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Bibliographic Details
Main Authors: Antti Siltanen, Kristo Nuutila, Yukiko Imanishi, Hisazumi Uenaka, Johanna Mäkelä, Tommi Pätilä, Antti Vento, Shigeru Miyagawa, Yoshiki Sawa, Ari Harjula, Esko Kankuri
Format: Article
Language:English
Published: SAGE Publishing 2016-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368915X688254

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