EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. The inevitable tradeoff of this plasticity is spontaneous receptor activation and spurious...

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Bibliographic Details
Main Authors: Martin Baumdick, Yannick Brüggemann, Malte Schmick, Georgia Xouri, Ola Sabet, Lloyd Davis, Jason W Chin, Philippe IH Bastiaens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
vesicular EGFR trafficking
spontaneous phosphorylation
autocatalysis
recycling endosome
partitioned phosphatase activities
ubiquitination
Online Access:https://elifesciences.org/articles/12223

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