Are vaspin and omentin-1 related to insulin resistance, blood pressure and inflammation in NAFLD patients?

• Main Authors: Aliasghari Fereshteh, Izadi Azimeh, Jabbari Masoumeh, Imani Bahareh, Pourghassem-Gargari Bahram, Asjodi Foad, Ebrahimi Sara
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2018-01-01
• Series: Journal of Medical Biochemistry
• Subjects: insulin resistance; nafls; adipokines; lipid profiles; inflammation
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581804470A.pdf

Background: Non-alcoholic fatty liver disease (N AFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure. Methods: This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omen-tin-1, vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed. Results: Partial correlations controlling for age and sex showed significant positive correlation between vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between omentin levels and systolic blood pressure (SBP). Conclusions: This study shows that vaspin and omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD.