Statistical use of argonaute expression and RISC assembly in microRNA target identification.

Statistical use of argonaute expression and RISC assembly in microRNA target identification.

MicroRNAs (miRNAs) posttranscriptionally regulate targeted messenger RNAs (mRNAs) by inducing cleavage or otherwise repressing their translation. We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivat...

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Bibliographic Details
Main Authors: Stephen A Stanhope, Srikumar Sengupta, Johan den Boon, Paul Ahlquist, Michael A Newton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2739424?pdf=render

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