Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never been reported. In this study, Caco-2, Calu-3, Mad...

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Bibliographic Details
Main Authors: Tomoyuki Furubayashi, Daisuke Inoue, Noriko Nishiyama, Akiko Tanaka, Reiko Yutani, Shunsuke Kimura, Hidemasa Katsumi, Akira Yamamoto, Toshiyasu Sakane
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
caco-2
calu-3
mdck
three-dimensional mucociliary tissue model system
nasal drug absorption
apparent permeability coefficient
Online Access:https://www.mdpi.com/1999-4923/12/1/79

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