Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors

Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors

Malignant melanoma is the most aggressive type of skin cancer and is closely associated with the development of brain metastases. Despite aggressive treatment, the prognosis has traditionally been poor, necessitating improved therapies. In melanoma, the mitogen activated protein kinase and the phosp...

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Bibliographic Details
Main Authors: Synnøve Nymark Aasen, Himalaya Parajuli, Tuyen Hoang, Zichao Feng, Krister Stokke, Jiwei Wang, Kislay Roy, Rolf Bjerkvig, Stian Knappskog, Frits Thorsen
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
brain metastasis
BRAF
MAPK
PI3K
combined treatment
apoptosis
Online Access:https://www.mdpi.com/1422-0067/20/17/4235

Internet

https://www.mdpi.com/1422-0067/20/17/4235

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