Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block.

Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block.

Since ancient times ursodeoxycholic acid (UDCA), a constituent of bile, is used against gallstone formation and cholestasis. A neuroprotective action of UDCA was demonstrated recently in models of Alzheimer's disease and retinal degeneration. The mechanisms of UDCA action in the nervous system...

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Bibliographic Details
Main Authors: Yevgenij Yanovsky, Stephan R Schubring, Quiaoling Yao, Yan Zhao, Sha Li, Andrea May, Helmut L Haas, Jian-Sheng Lin, Olga A Sergeeva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3412845?pdf=render

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