Application of Thermodynamics and Protein–Protein Interaction Network Topology for Discovery of Potential New Treatments for Temporal Lobe Epilepsy

Application of Thermodynamics and Protein–Protein Interaction Network Topology for Discovery of Potential New Treatments for Temporal Lobe Epilepsy

In this paper, we propose a bioinformatics-based method, which introduces thermodynamic measures and topological characteristics aimed to identify potential drug targets for pharmaco-resistant epileptic patients. We apply the Gibbs homology analysis to the protein–protein interaction network charact...

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Bibliographic Details
Main Authors: Chang Yu, Edward A. Rietman, Hava T. Siegelmann, Marco Cavaglia, Jack A. Tuszynski
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
epilepsy
systems biology
protein–protein interactions
CNS
Gibbs homology
drug targets
Online Access:https://www.mdpi.com/2076-3417/11/17/8059

Internet

https://www.mdpi.com/2076-3417/11/17/8059

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