MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression

MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression

Tumor suppression: another link in a signaling chain New drugs to fight tumors could be developed, thanks to research revealing how a protein called MSK1 interacts with and assists another protein, “p53,” which has well-established tumor-suppressing activity. Researchers led by Jeong Hyeon Park at M...

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Main Authors: Jihye Ahn, Jin Gyeong Lee, Chuevin Chin, Suna In, Aerin Yang, Hee-Sung Park, Jaehoon Kim, Jeong Hyeon Park
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0160-8
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spelling doaj-4f3501e6cd254cb7a1ae90ec767306ac2020-12-08T13:51:49ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-10-01501011210.1038/s12276-018-0160-8MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expressionJihye Ahn0Jin Gyeong Lee1Chuevin Chin2Suna In3Aerin Yang4Hee-Sung Park5Jaehoon Kim6Jeong Hyeon Park7Department of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyInstitute of Fundamental Sciences, Massey UniversityDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Chemistry, Korea Advanced Institute of Science and TechnologyDepartment of Chemistry, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyInstitute of Fundamental Sciences, Massey UniversityTumor suppression: another link in a signaling chain New drugs to fight tumors could be developed, thanks to research revealing how a protein called MSK1 interacts with and assists another protein, “p53,” which has well-established tumor-suppressing activity. Researchers led by Jeong Hyeon Park at Massey University in New Zealand and Jaehoon Kim at the Korea Advanced Institute of Science and Technology in South Korea studied the function of the MSK1 protein in cultured human cells. They uncovered details of a previously unknown direct interaction between the MSK1 and p53 proteins. This allows the MSK1-p53 combination to increase the activity of a gene that codes for another protein, p21. The p21 protein then participates in further molecular processes that can restrict cell growth and multiplication. Drugs that control MSK1 activity might offer new opportunities to combat the uncontrolled multiplication of cancer cells.https://doi.org/10.1038/s12276-018-0160-8
collection DOAJ
language English
format Article
sources DOAJ
author Jihye Ahn
Jin Gyeong Lee
Chuevin Chin
Suna In
Aerin Yang
Hee-Sung Park
Jaehoon Kim
Jeong Hyeon Park
spellingShingle Jihye Ahn
Jin Gyeong Lee
Chuevin Chin
Suna In
Aerin Yang
Hee-Sung Park
Jaehoon Kim
Jeong Hyeon Park
MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
Experimental and Molecular Medicine
author_facet Jihye Ahn
Jin Gyeong Lee
Chuevin Chin
Suna In
Aerin Yang
Hee-Sung Park
Jaehoon Kim
Jeong Hyeon Park
author_sort Jihye Ahn
title MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
title_short MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
title_full MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
title_fullStr MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
title_full_unstemmed MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
title_sort msk1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression
publisher Nature Publishing Group
series Experimental and Molecular Medicine
issn 1226-3613
2092-6413
publishDate 2018-10-01
description Tumor suppression: another link in a signaling chain New drugs to fight tumors could be developed, thanks to research revealing how a protein called MSK1 interacts with and assists another protein, “p53,” which has well-established tumor-suppressing activity. Researchers led by Jeong Hyeon Park at Massey University in New Zealand and Jaehoon Kim at the Korea Advanced Institute of Science and Technology in South Korea studied the function of the MSK1 protein in cultured human cells. They uncovered details of a previously unknown direct interaction between the MSK1 and p53 proteins. This allows the MSK1-p53 combination to increase the activity of a gene that codes for another protein, p21. The p21 protein then participates in further molecular processes that can restrict cell growth and multiplication. Drugs that control MSK1 activity might offer new opportunities to combat the uncontrolled multiplication of cancer cells.
url https://doi.org/10.1038/s12276-018-0160-8
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