Synthesis and antitumor activity of benzo[6″,7″]cyclohepta[1″,2″:4′,5′]pyrido[2′,3′-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones

Synthesis and antitumor activity of benzo[6″,7″]cyclohepta[1″,2″:4′,5′]pyrido[2′,3′-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones

2-Thioxo-3,9,10,11-tetrahydro-1-phenyl-benzo[6′,7′]cyclohepta[1′,2′:4,5]pyrido[2,3-d]pyrimidin-4-one (4) was prepared by the reaction of 2-dimethylaminomethylenebenzosuberone (1) with 6-amino-1-phenyl-2-thioxo-2,3-dihydro-pyrimidin-4-one (2). 2-Hydrazino-9,10,11-trihydro-1-phenyl-benzo-[6′,7′]cycloh...

Full description

Bibliographic Details
Main Authors:	Mastoura M. Edrees, Thoraya A. Farghaly
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Arabian Journal of Chemistry
Subjects:	Hydrazones Penta-heterocyclic compounds Oxidative cyclization HEPG-2 “liver” cancer cell line MCF-7 “breast” cancer cell line
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535213001664

Similar Items

Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3+ + 2]-cycloaddition/rearrangement reactions
by: Lin-bo Luan, et al.
Published: (2018-07-01)

Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties
by: Heba A. Elhady, et al.
Published: (2018-05-01)

Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1<em>H</em>)-diones
by: Thoraya Abdel Reheem Farghaly, et al.
Published: (2012-07-01)

Synthesis and Cytotoxic Evaluation of 3-(4-Fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitrophenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide Analogues
by: Mohamed J. Ahsan, et al.
Published: (2018-04-01)

IBD-mediated oxidative cyclization of pyrimidinylhydrazones and concurrent Dimroth rearrangement: Synthesis of [1,2,4]triazolo[1,5-c]pyrimidine derivatives
by: Caifei Tang, et al.
Published: (2013-11-01)

Synthesis of 3-Trifluoromethyl-5,6-dihydro-[1,2,4]triazolo Pyrazine Derivatives and Their Anti-Cancer Studies
by: Rajaiah Raveesha, et al.
Published: (2020-12-01)

Synthesis of 2-(4-Methoxyphenyl)pyrrolo[2,1-d]pyrido[2,3-c]-[1,5]-thiazepin-3(2H)-one
by: Eunsook Ma
Published: (2003-08-01)

Utility of 2-thioxo-pyrido[2,3-d]pyrimidinone in synthesis of pyridopyrimido[2,1-b][1,3,5]-thiadiazinones and pyridopyrimido[2,1-b][1,3]thiazinones as antimicrobial agents
by: Yasser H. Zaki, et al.
Published: (2017-06-01)

4-[5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide
by: Muhammad Taha, et al.
Published: (2014-05-01)

4-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide
by: Imran, S., et al.
Published: (2014)

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents
by: Sayed AR, et al.
Published: (2020-04-01)

Synthesis of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives and evaluation of their anticancer activity
by: Nitin Kumar, et al.
Published: (2017-05-01)

Synthesis and crystal structure of N-(4-chlorophenyl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine
by: Hlib Repich, et al.
Published: (2017-01-01)

Synthesis of ([1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl)phosphonates and their benzo derivatives via 5-exo-dig cyclization
by: Aleksandr S. Krylov, et al.
Published: (2019-07-01)

Synthesis of 1,3,4-Oxadiazole Derivatives from Ethyl-2-Piperidone-3-Carboxylate
by: M. A. Sheat, et al.
Published: (2012-03-01)

Synthesis and Antibacterial Activities of Novel 2,5-Diphenylindolo[2,3-e] Pyrazolo[1',5':3",4"]pyrimido[2",1"-c] [1,2,4]triazines
by: Mohamed G. Marei, et al.
Published: (2011-12-01)

Ethyl (1,3-diphenyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)acetate
by: Sobhi M. Gomha, et al.
Published: (2011-11-01)

Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity
by: Hessa H. Al H. Al Rasheed, et al.
Published: (2020-06-01)

Synthesis, characterization, antioxidant and anticancer evaluation of some novel flavone-4-oximes
by: B.S. Jayashree, et al.
Published: (2016-02-01)

Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
by: Kamal F.M. Atta
Published: (2011-08-01)

Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
by: Heba A. El-Hady, et al.
Published: (2017-05-01)

Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells
by: Andi Nur Fitriani Abubakar, et al.
Published: (2017-05-01)

Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
by: Naim H. Al-Said, et al.
Published: (2013-12-01)

(E)-Ethyl 3-(Dimethylamino)-2-(7,9-diphenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-2-yl)acrylate
by: Sobhi M. Gomha, et al.
Published: (2011-12-01)

4a,5,9,10,11,12-Hexahydro-6H-benzo[a]cyclohepta[hi]benzofuran - Synthesis of Unnatural Galanthamine Analogs
by: Ulrich Jordis, et al.
Published: (2002-04-01)

(E)-4-Chloro-N′-(2,4,5-trifluorobenzylidene)benzohydrazide
by: R. Maheswari, et al.
Published: (2016-03-01)

Crystal structure of N′-[(E)-3,5-dichloro-2-hydroxybenzylidene]-4-nitrobenzohydrazide dimethylformamide monosolvate
by: Bibitha Joseph, et al.
Published: (2015-11-01)

Synthesis, characterization and antimicrobial evaluation of the novel pyrido[1',2':2,3][1,2,4]triazolo[1,5-c]quinazolines and thiazolo[3',2':2,3][1,2,4]triazolo[1,5-a]pyridines
by: Azza Mohamed El-Kazak, et al.
Published: (2013-06-01)

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[<i>b</i>]Thiophene-3-Carboxylate: Synthesis,<i> </i>In Vitro, and In Vivo Activity Evaluation
by: Emad M. Gad, et al.
Published: (2020-05-01)

In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells
by: Hussain S, et al.
Published: (2019-12-01)

Antimicrobial and anticancer evaluation of a novel synthetic tetracyclic system obtained by Dimroth rearrangement
by: Gomha Sobhi M., et al.
Published: (2015-01-01)

Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4‑Substituted 9H‑Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3‑d]pyrimidines
by: Lucia Veselovská, et al.
Published: (2020-10-01)

Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells
by: Renata C. Costa de Freitas, et al.
Published: (2017-12-01)

Anticancer and apoptosis-inducing effects of Moringa concanensis using hepG2 cell lines
by: V. Balamurugan, et al.
Published: (2014-11-01)

1-Benzyl-2-(thien-2-yl)-4,5-dihydro-1<i>H</i>-imidazole
by: Alexandra S. Golubenkova, et al.
Published: (2020-05-01)

Synthesis and antioxidant activity of 2-methylthio-pyrido[3,2-e][1,2,4] triazolo[1,5-a]pyrimidines
by: Abuelizz Hatem A., et al.
Published: (2019-10-01)

Novel 3-Acetyl-2,5-Disubstituted-1,3,4-Oxadiazolines: Synthesis and Biological Activity
by: Kinga Paruch, et al.
Published: (2020-12-01)

Synthesis and Spectroscopic Properties of New Azo Dyes Derived from 3-Ethylthio-5-cyanomethyl-4-phenyl-1,2,4-triazole
by: Mariam Al-Sheikh, et al.
Published: (2014-03-01)

Evaluation of Pharmacological Effective Concentrations of Aspirin with/without Radiotherapy on MCF-7Breast Cancer Cell Line
by: Negin Farhad, et al.
Published: (2018-07-01)

Crystal structure of 5-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-2-methoxyphenol
by: Farook Adam, et al.
Published: (2015-12-01)