Adenosine Receptor Activation in the “Trigger” Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s)

Adenosine Receptor Activation in the “Trigger” Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s)

Remote ischemic pre-conditioning (rIPC) has emerged as a potential mechanism to reduce ischemia-reperfusion injury. Clinical data, however, have been mixed, and its physiological basis remains unclear, although it appears to involve release of circulating factor(s) and/or neural pathways. Here, the...

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Bibliographic Details
Main Authors: Hussain Contractor, MBChB, DPhil, Rasmus Haarup Lie, MD, PhD, Colin Cunnington, MBChB, DPhil, Jing Li, PhD, Nicolaj B. Støttrup, MD, PhD, Cedric Manlhiot, BSc, Hans Erik Bøtker, MD, PhD, Michael R. Schmidt, MD, PhD, J. Colin Forfar, MD, PhD, Houman Ashrafian, MB BChir, DPhil, Andrew Redington, MBBS, PhD, Rajesh K. Kharbanda, MBChB, PhD
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:JACC: Basic to Translational Science
Subjects:
adenosine
endothelium
ischemia
pre-conditioning
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300614

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http://www.sciencedirect.com/science/article/pii/S2452302X16300614

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